The ocular surface consists of the cornea (clear window to the eye), conjunctiva (skin of the eye), and the tear film that protects and hydrates the cornea and conjunctiva. The ocular surface is extremely complex, anatomically and physiologically. Disorders of the ocular surface are the most common of all eye conditions, and include dry eye, conjunctivitis, corneal scarring, superior limbic keratoconjunctivitis, or stem cell deficiency secondary to ocular cicatricial pemphigoid, Stevens Johnson Syndrome, or another degenerative conditions. Symptoms of ocular surface disease include pain, irritation, redness, blurry vision that goes in and out, mucous discharge and lashes that rub on the eye. Treatment requires a careful evaluation to achieve a proper diagnosis. There are many different surgical and non-surgical approaches to treating ocular surface disease, from ocular lubrication to ocular surface reconstruction.